After a trip to Owen's home town, Alexia got sick, and was told not to return to work until she was better. During the two weeks she was gone, Owen started to think of more serious things for their relationship, even going so far as buying her a ring. Due to his anxiety, though, he didn't actually get the chance to propose to her, and the two ended up spending the night together instead. While Alexia was asleep, Owen put the proposal into a note, planning to give it to her the next morning. That morning, though, they ended up arguing over Owen meeting Alexia's Grandmother. Before she stormed off, Owen handed her the note, with the ring also tucked safely inside, and told her to open it when she wasn't upset anymore. Once she left, Owen decided to stay home from work, and give Alexia a chance to cool off.
While at home that day, Owen got a visit from Claire Dearing, the park operation's manager. After a brief argument with her, Owen reluctantly accompanied the redhead to the Indominus Rex paddock he was to evaluate. Once inside the observation room, though, the dinosaur appeared to have climbed out of her paddock. Claire panicked and headed back to the control room to track it, while Owen, and one of the handlers for the hybrid, investigated the inside of the paddock. They realized too late that it had been a trick played by the dinosaur, and while trying to escape being eaten, one of the handers accidentally let the Indominus out of her paddock. He was killed, but Owen survived by hiding under a car and covering himself in fuel, so that the dinosaur wouldn't smell him.
Once back at the park, Owen entered the control room, where he witnessed a team of ACU agents try and contain the Indominus, only to be killed. After suggesting that ACU kill the animal, Claire kicked Owen out of the control room, only to run to him for help with finding her nephews a little while later. Owen agreed, and the two headed out to look for the boys, finding several dead Apatosaurus' on the way. Eventually, Owen and Claire found evidence that the boys were in the restricted part of the park, and Owen tried to send Claire back. She protested, of course, and ended up staying, both of them tracking her nephews to the old Visitor's Center of the original park. Before they could find a way back, though, the Indominus found and tried to attack them, the two barely escaping the hybrid, before watching ACU fail at trying to stop the Indominus for a second time., and watching Simon Masrani, the owner of the park, die in a helicopter crash, as he had been trying to help kill the Indominus.
After returning to the park once again, now on the run from the dinosaurs that had escaped the park's Aviary, Owen and Claire ran into Alexia, her friend Savannah, and Claire's nephews. After Owen got the answer to his proposal from Alexia, the entire group headed for the raptor paddock, where Hoskins, one of the InGen members, was planning to use the raptors to hunt the Indominus. Owen was against the idea, but after Hoskins started guilt tripping him, he reluctantly agreed, and Owen, Alexia, Barry, and a team of InGen soldiers headed out with the raptors to look for the Indominus. The plan went haywire, though, when the Indominus and the raptors began communicating, and the InGen soldiers opened fire on the hybrid, scaring the raptors in the process. The raptors are scattered, and after nearly being killed by a rocket that was meant for Charlie, Owen and Alexia headed back to the raptor paddock, then to the Innovation Center with Claire and the others.
Once back at the innovation center, Owen and the others headed for the Control Room. They ran into Hoskins on the way there, though, and witnessed Delta, one of Owen's raptors, kill the man. While Delta was distracted, they ran again, but were stopped by Blue once outside. The raptors had them surrounded, but Owen was able to reconnect with Blue and call them off. The Indominus ordered Blue to attack, but she didn't, and she was thrown into abuilding. Owen, thinking the Beta raptor was dead, stayed out while the others ran for safety, sic'ing his other two raptors, Delta and Echo, on the Indominus. Both raptors were thrown, though, and Owen moved for cover, only to have the Indominus follow him. It attacked again, and while trying to prevent Gray from being eaten, Owen had a small panic attack, but it was quickly calmed down by Alexia being in the vicinity.
Just before the Indominus attacked yet again, the T-Rex (thanks to Claire) intervened, and Owen helped pull the others to safety, then watched as the Rex was thrown to the ground. Right before it was killed, though, Blue, who Owen thought was dead, came to the rescue and attacked, giving the Rex a chance to get up. The Rex and Blue worked together for the fight, eventually pushing the Indominus to the Moasasaur pit, where it was then pulled under by the prehistoric fish. As soon as the coast was clear, Owen and Alexia moved to confront Blue. She was proud and wanted to stay, but Owen, knowing it was too dangerous, set her free, watching her and Echo run off, before he and the rest of the group headed to Costa Rica with the others that had been rescued from the Island.